Research about apigenin

 

1) INTRODUCTION

Chronic diseases, particularly in industrialized nations, constitute a significant burden on global public health. Examples include cancer, diabetes, Alzheimer's disease, stroke, depression, and age-related function decline.
Regular exercise and a healthy diet are thought to help prevent these and other diseases as well as fight those that have already manifested.
An emphasis has been placed on eating a diet rich in fruits and vegetables, which are natural sources of bioactive chemicals with beneficial effects on health.  

2) APIGENIN  

Apigenin is a flavonoid found in plants that has been shown to have many health benefits, including longevity.

 Apigenin is a natural compound found in plants such as parsley, celery, and chamomile. It has been shown to have anti-inflammatory and anti-oxidant properties.

Apigenin is a plant compound found in many fruits and vegetables, such as parsley, celery, grapes, and apples. Apigenin has been shown to increase lifespan and promote healthy aging by activating the CD38 gene.

 The research on apigenin is still in its early stages, but it has been proven to increase lifespan in animal models. The mechanism of action is not fully understood yet, but the most likely candidate for the longevity effect is the inhibition of CD38 expression by apigenin.

 Numerous plant bioactive substances have demonstrated functional properties that imply they might have a significant impact on preventing a variety of chronic diseases.
The flavonoids, which include apigenin, make up the biggest class of naturally occurring polyphenols.
This revised summary of apigenin concentrates on its medicinal properties and health-promoting effects, in particular the findings of in vivo research.
Its chemistry has been introduced, and nutraceutical characteristics have also been discussed.
The primary takeaways from in vivo investigations using both human and animal models are outlined.
The positive benefits, which include those on diabetes, amnesia and Alzheimer's disease, depression and sleeplessness, cancer, etc., are recorded and covered in length. 

In order to demonstrate the crucial role that apigenin plays in the assessment of a formed diet and in dietary assessment, data on flavonoids from the most important public databases are compiled, as well as information on exposure and in vivo health consequences. 

Apigenin is one of the most well-known phenolic compounds, with a wide range of beneficial nutritional and organoleptic properties.
However, and this is more intriguing, it may also contribute to health benefits, which might make it a possibility to be included in nutraceutical formulations. 

The wide range of pharmacological effects of apigenin and its significance for human health make a thorough understanding of its mechanism of action essential for any future use in nutraceuticals.
The pool of secondary metabolites for food or part of food of animal origin, as well as the phytocomplex for food or part of food of vegetal origin, are both considered nutraceuticals in this context. Stephen De Felice originally invented the term nutraceuticals. 

Numerous research conducted over the years have shown that apigenin has a wide range of intriguing pharmacological actions and potential for use in nutraceuticals.
For instance, its antioxidant effects are widely known, and it can also be used as a therapeutic agent to treat conditions including inflammation, autoimmune, neurological, and even a few different types of cancer.
Compared to other structurally related flavonoids, it has a lower inherent toxicity on normal than malignant cells.
Despite its significance, little is known about the health benefits of apigenin for humans, including its capacity to reduce inflammation or improve cognitive function, both of which are important potential uses

 

Growing interest in apigenin as an useful and health-improving substance has occurred recently.

A recent summary of apigenin's various therapeutic uses using in vitro and in vivo systems was published by Kashyap et al.
Apigenin's potential therapeutic effects were investigated through a variety of pathways, including cell cycle arrest, apoptosis, anti-inflammatory effects, and antioxidant activity.

Although there have been quite a few in vitro investigations on the properties of apigenin, there have only been a few in vivo studies employing mice, rats, or hamsters as models.
For clinical trials involving humans, the situation is significantly worse.
The fact that there are so few of these studies, particularly in the area of how this substance affects cancer, may be attributed, among other things, to ethical considerations.
For the investigations on animals and humans , we separately summarized the key findings. 

3) CONCLUSION

According to the in vivo and in vitro evidence presented here, apigenin, a naturally occurring bioactive flavone-type molecule, may be crucial in the prevention and treatment of new global health problems, underscoring once more the important role that food and/or plant compounds play in human health.
Given the considerable inter-individual variability, it is highly challenging to obtain general or unambiguous information about its preventive effect within the human body, its bioavailability and bioactivity, and the various biological systems impacting human health.